Will this RAM work on Z170?

I thought Z170 boards were only dual channel, but I have read you can use quad channel kits on them, is that correct?

I am wondering if THIS KIT will work? If so, any drawbacks in doing so vs x2 dual channel sets?

Skylake is a dual-channel system, but a quad-channel kit is just 4 matched sticks rather than 2.

For a 32GB Skylake Z170 build, that kit will be absolutely fine - probably better than getting 2 dual channel kits as it's a kit of 4 matched sticks.

For an X99 build, you'd want to go with quad channel rather than 2x dual, because it can be a bit funny with certain kits/combinations.

Great thanks... I found it a bit odd that Skylake doesn't talk much about quad channel compatibility, which is what initially caused me to think it wouldn't work. Good to know though.

The Skylake architecture is dual-channel - you have banks of 2 DIMMs. X99 is quad - banks of 4. The memory manufacturers produce kits for each platform, so Skylake kits are dual-channel and Haswell-E are quad-channel.

If you put a quad-channel kit in a Skylake board, it behaves like 2 dual channel kits with the added bonus that all the sticks come from a matched kit. It can also be cheaper as well.