There are plenty of reports of popping and black screens on NVIDIA, now, too.
It seems to be both a panel and CVT timing problem (not necessarily signal loss).
Tbh, I won't be bothering with 4K until the next generation of graphics cards (even if a brilliant 120/144hz 4K panel comes out in the mean time). Panels will hopefully be more reliable by then, and video cards / drivers will be working properly.
Post from Silent Scone on Overclock.net
I've been helping AMDs driver team with this one and it is definitely an issue with the timings. Least on the AOC. Need to speak with them again in the morning (I'm from UK)
It seems that the timing being used by this monitor violates the CVT spec from VESA. Both vertical and horizontal porches are out of spec.
We think that we can make an EDID patch (INF file) as a quick, short term solution.
It would appear that AOC (and possibly others) have released a product that does not meet basic compatibility requirements.