10000%
My other half, she of tiny hands, was all "these big phones are stupid" then I got her a Note 9, now she's onto an S10+
The amount of time you actually use them one handed (generally) is minuscule.. for all the rest of the time you have a bigger screen, bigger battery, better specs.
Just do it, it's totally fine. Going back to a smaller phone for me is torture.
For me, it's not so much the using it one handed, it's carrying a bigger phone in my pocket, particularly during the summer when I'm going to be wearing shorts some days, or when I'm at the gym. I got really sick of the general size of my OP5T, it would jab me in the hip when I sat down and I was always worried about it slipping out of my pocket when I sat down (due to the fact it was so large that it sat closer to the top of trouser/short pockets). Personally I think the optimal screen size for a phone is about 6" (particularly in an all-screen phone), which the S10e is just short of.
Also, I basically don't ever watch video on my phone, I've got my TV and PC for that, so a bigger screen would be mostly redundant for me. The S10e screen is plenty for my general phone usage of social media, emails, messaging, and internet browsing.
and if you get a not clear case it'll cover that up. I'm slightly biased but the Samsung original soft touch cases are very nice 
, slightly smaller battery however it's powering a smaller and lower resolution display so much of a muchness in overall battery life. Screen is FHD and not QHD but at that size you'll never tell in the real world.
