I am by no means an expert, so don't take my suggestions as gospel.
In a traditionally shaped case like the R5, I'd personally aim to keep to horizontal airflow (front case fans as intakes and rear case fans as exhaust), with as little turbulence as possible. Having vented PCI plates/covers, or just removing the excess ones entirely may help with this.
Then for the case fan input sensors, I'd try to have them all based on the same input that would somewhat represent the internal case temperature (e.g. VRM, motherboard or system temperature) and they'd all increase/decrease at the same time. The rear case fan might need to be set at more aggressive RPMs if your intake fans are pulling in too much air.
Test it out though and just go with whatever you prefer.