Auto or safe it's always 2133, anything above is considered OC, but that's what XMP profiles are for, or manual tuning, usually after BIOS update these settings are wiped, but that's why you have the options to save & load profiles in many motherboards (thou be careful with that, sometimes loading old profile on new BIOS may have funny results)
You have to enable XMP, DOCP for ASUS, so it'll set them to target 3600CL18 (at least the basic timings are done by XMP). FCLK should follow automatically as it's not super high but you shpuld check if it's on 1800 after you enable DOCP, if not set it to 1800.
and then... either you're lucky and everything works and you can start tweaking, or it'll become unstable and you'll have to fix it. Usually fastest tweak, or 99% stable configuration is 3200MHz with FCLK on 1600MHz, if that doesn't work then it's very bad. But 3600/1800 combo should be rather easy.