See this is why I find it hard to be reassured - granted they don't seem to pose any specific dangerous health problems but as a kid (early 80s) I had sensitivity to certain E numbers (mostly tartrazine) - I'd change like flicking a switch between my normal quite passive and easy going to full on shouting and swearing at people, etc. full on hyperactivity - one time when I was in hospital having tonsils out IIRC the nurses in hospital pretty quickly swapped the medication I was on as they narrowed it down to the artificial flavouring in the medicine. At the time all the studies showed "no evidence" of anyone having sensitivity, etc. and there was a lot of dismissal it could even remotely be a possibility. These days as an adult I'm relatively tolerant to it though. Now there is a "possible" link https://www.nhs.uk/conditions/food-colours-and-hyperactivity with the commercial investment of the times with the increasing use of artificial colours and flavourings any problems were pretty much suppressed. So these days I am very very sceptical.