The simple answer is Yes. All an asynchronous DAC is doing is providing a more accurate transfer of data via the PC's USB connector. How it does this is by the DAC having its own data clock which is said to be more accurate than the one in a PC.
There are a few caveats though...
Firstly, the idea of running an asynchronous DAC is is really a Hi-Fi purist thing. The typical amp would be an all-analogue affair. By contrast, many of the AV receivers on the market including those that feature a "Pure Audio" mode still have digital signal processing running in the background. Tip: If you can use "Pure Audio" mode with an audio signal via HDMI, or optical, or coax then it's not a true all-analogue signal path.
On the PC side, the USB port needs to support asynchronous transfer. Some information suggests that this is only possible with USB 3.0 (A.K.A.
SuperSpeed USB).
On the receiver side, you need to be sure that the receiver doesn't digitise the incoming analogue signal from the DAC. It would be a waste to have spent time and money ensuring the cleanest and most accurate data transfer and decoding, only for the AV receiver then to undo all the benefits by converting the signal back in to digital for it's own internal processing. Make sure your receiver has an all-analogue throughput mode so it doesn't trash the music.
Third, make sure your speakers are up to the job. Sub/sat speakers are out. If you want to preserve the integrity of the music then your front speakers need to be full range Hi-Fi speakers. You'll be running the receiver in pure stereo (digital bypass) mode, which also means the sub won't be active either. If the amp is driving the sub then it means it has digitised the signal, and so potentially chucked away the benefits of your super-duper DAC.
Finally, it's the files themselves. You can't polish a turd.

If your file rips are lossy then the data is already gone. Spending money on a clever DAC isn't going to get back what's been thrown away... no matter what the advertising material says.
As long as the files, the PC, the AV receiver and the speakers are all up to the job then you may well hear some benefits. If there's one weak link in the chain though then you might be chucking all the benefits down the drain.