Hi,
I have had experience with both boards.
The Asus can work very well, but overclocking with this board still has mixed results. A 260htt, should work fine, hitting 300 can be tricky, more so if running Crossfire. There are also a few annoying problems with bios boot ups after applying overclocks. The onboard sound always has a level of backgorund noise, which is related to data access, which is a shame, it's not loud, but you can always hear it when using headphones. In terms of performance I think Asus have squeezed most of it. If they can fix some of the remaining isses it would become a great value for money board.
The DFI board has worked great for me, I used an ATI overclocking guide right from the start, no problems whatsoever. I've found this board to be overclock friendly. The board has a lot going for it, most of the major issues with the bios have already been ironed out, with Tony working with DFI to get the best out of the board as quickly as possible. The onboard sound is very good. The only annoying issue being reported atm is with regards to the Silicon Image setup. Though I only use the ULI for raid, so the problem does not apply to me anyway. I'm sure this issue will be fixed very soon.
edit: there's also an issue being reported with usb keyboards, I use ps2, so I guess I'm lucky. My take is that the above issues are just bios related, and can be ironed out. DFI also states the bios fixes with each upgrade unlike Asus, who seem to cover up the fixes with a rather uninspiring phrase.
The DFI is a very expensive board, but it's great (IMO), the Asus is satisfactory, the price is great..
One other to consider is the ABIT which is the 'safe' option. Coolasmoo has one, reporting a glitch free setup, with no major bios issues atm. The price is good, it has a more stable vcore than the Asus too. Though I've heard a report that 270htt is about the max the current bios allows.
I can't really suggest which one is better for you, I've tried to post my experience so far, hope it helps.
regards
Raja