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Hmm, are you suggesting reliable consumer-grade RAM or going all the way with ECC?
There are a couple of approaches you can take on this.
One is to do enough testing (e.g. memtest86+ for a few passes) with your set-up to know that the actual RAM you have is not faulty in the first place (at stock settings) and then testing at a range of overclocked settings to see at which point errors are seen, then backing away by the amount of safety margin you want. The limitation is that this does nothing about the risk of a fault developing at some point in the future and not knowing about it (at least, not without tedious repeat testing).
The other is to use ECC (and ensure your host is configured to report and alert hardware errors); you'll trade-off price and potential memory speed (compared to enthusiast-grade overclockable RAM) but ECC exists to address this concern.