You may be able to if you have an Asus motherboard with the AINap feature:
"Minimize noise and power consumption when temporarily away
With AI Nap, users can instantly snooze your PC without terminating the tasks. System will continue operating at minimum power and noise when user is temporarily away. It keeps downloading files or running applications in quietest state while you´re sleeping. Simply click keyboard or mouse, you can swiftly wake up the system in few seconds."
Not sure if other brands have anything equivalent.