Water-cooling is understandably not a focus for a case like this, but nevertheless the Focus G Mini does have some decent options here, with 240mm radiators supported in both the front and roof mounting positions, limited to 45mm and 35mm thickness respectively. The front position also needs the lower optical drive bay to be unoccupied; there's a cutout in the cage to allow the radiator to poke through. The lower HDD cage is removable, but it can't be moved anywhere without modification, so you'll be left with just a single, difficult-to-access 2.5” mount if you go this route. The ODD cage, meanwhile, is not removable.