There's some good sighting opportunities for this flight. If you're able to get clear skies on Thursday and Friday night, you should be able to spot both the ISS and Discovery as separate points of light:
ISS - Thursday 4th, approaching from SWW (south west west) at 17:01, raising to a maximum elevation of 58 degrees before disappearing into the Earth's shadow after 3 minutes.
Similar story on each night following: one favourable pass each night lasting about three minutes between 5 and 6pm.
On Thursday night, the Shuttle will follow the same path as the ISS - only 7 minutes later. The big one, however, is going to be Friday the 5th. Hardly a firework show, but the ISS and Shuttle should have just docked and the stack should look very bright!
Sighting opportunities really start to diminish toward the end of the missions thanks to the time of year and the ISS's orbit, so catching Discovery on Thursday night before docking will be your last chance to see the orbiter on orbit on it's own.
EDIT: Pick your nearest major town from
this list to get sighting opportunities for where you live. They are most favourable in the south. Incidentally, the highest (most northerly) point of the ISS's orbit brings it right over my house! 89.8 degrees straight up!