Soldato
Depends what "mixing" ram means. Given how Threadripper is working, with each chip having access to it's own ram banks, assuming someone buys two identical dual channel kits (and i mean IDENTICAL in brand, speed, even manufacturing day) I wont be surprised to be non issue, compared to intel where the memory is more sensitive because is shared as whole across the CPU.
Just don't. It may work, it may not. Depends on the guardband the vendor is using. Memory is binned in the density it is sold in, by combining kits it doesn't matter if they're a serial number apart, you're still eating into the guardband and stability may not be possible at the same frequency, timings or voltage. It's fine if you want to do this yourself, just don't tell others to.
Also, I do understand what you're alluding to with the memory channels being segregated to two per die - but there are other factors involved, too.
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