Complete reboot of the series and Agent 47
Agent 47's got beard! (WTF?!)
Heavy focus on story
47's "assignments" are more open mission just like in the previous titles
The game features more linear missions when 47 isn't on an assignment, with focus on guns and cover
The game is being developed along with the second Hitman-movie
You get to play as other killers, not only 47. One of the assassins is a woman.
David Bateson is lending out his voice as 47 yet again
http://www.gamereactor.se/blog/mr clint/177457/