As said it depends, if its a standard card then use afterburner, its far far better. If its one of the Asus custom designs you have little choice.
Said this before, Asus have a really fancy piece of nice software for overclocking their "matrix" range of cards, and use smart doctor for everything else. All that needs adding is listing another voltage controller and enabling all Asus cards in the FAR better software, but they won't, its ludicrous.
Smart doctor might be the single worst piece of software I've used from any gpu making company, and there have been some really bad ones over the years.
It would have looked data 10 years ago, its buggy as hell, its incredibly slow to load and insists on another piece of software, also slow to load, to be installed to work correctly, they all take ages to load and even take long just to open from system tray or anywhere else.