So after playing with the beta on/off for a few days I'm still unable to make a profit

I started off by putting stops everywhere I could to cover the inner city, plenty of buses so passengers weren't waiting too long, fiddled with the fairs (usually in the red) to strike a nice balance between people waiting and profit. This didn't work as I quickly started loosing money.
Next thing I tried was to have 2 bus routes in the inner city covering slightly less than the last time (less stops = less maintenance), tram lines going around the out side and 2 bus routes taking passengers across the bridge to the factories. Fiddled with the staff wages and ticket fairs and also started a dedicated bus route with 1 bus to shuttle passengers from the airport to the city centre. Again this didn't work.
I have no idea where I'm going wrong, my staff are on the lowest possible wage (constantly changes due to the economy) and ticket fairs are usually quite high, so long as people are still willing to buy them.
I also changed the number of buses on each route to 2 or 3 but this also meant that lots of people were waiting and getting upset and I still lost money.
Has any of you guys managed to create a nice profitable game and are willing to share your secrets ?
