Left 4 dead 1 & 2.
Dead Rising 2.
Super Meat Boy... lol
Resident Evil 5.
Devil May Cry 4.
I think all of those are Xbox 360 pad compatible too.
My wife really enjoyed playing through Lara croft game of light with me.
Anything co-op or 2 player is good. There are some good driving games e.g blur & split second.
She is also a massive civ fan! But that is probably a bit random.
Bit of a cliche, but aren't girls supposed to like Sims?

the sims....
I suppose "nothing like the sims" could be interpreted that way... but no.