I've had it for years, but I still have a high QI
In all seriousness its not been a problem for me career wise (although I really struggle spelling career...) it was difficult at points through school and uni but I worked out coping methods.
It effects people in different ways, spelling being the most common, essentially its a distinct deficit in one skill set made up for (usually excessively) by another skill. For example I struggle with spelling and expressing what I mean in written form however I've got a very high visual-spacial awareness and good lateral thinking.
Coping with it is all about working around your weaknesses and using your strengths.