The OP has brought a lot of not too pleasant memories back for me as I (and my wife obviously) have been there, done that and got the T-Shirts!! We never had any luck either and it got to the point where the emotional stress was just too much so we gave up in the end. This was way back in 2001. We were trying for 3yrs via IVF. The only thing we got through the NHS at the time was 1 course of drugs. I will be honest I think we spent £10,000 altogether on IVF!
I have experienced all the stuff the OP has pointed out - the guilt of watching your wife having to have injections was horrible for me. Now I hate injections and the sight of needles literally frightens me to death but I had to overcome it and do them for her. I couldn't let her go through that on her own. Then there was the guilt of her ending up being rushed into hospital a few days after one of the egg collection procedures as her ovary nearly burst. I didn't realise at the time how serious this could have been. Due to the infertility issues we had the doctors needed to get as many eggs as possible to give us a chance so the hormones she had to have were of a much higher dose. Due to that the ovaries obviously over expand. She ended up in hospital for 4 days because of that.
I am going to backtrack here a bit as I have just spotted something in the OP that has caught my eye. I wasn't going to reveal what our issues were in case some smart a**e takes the mickey a bit but bugger it as I want to try and help. I have just spotted that the OP has been given the "unexplained fertility" line. We had that. Now, unbeknown to me at the same time my brother and his wife were also going through the hospital visits to try and find out the problems. My brother is a lot more pushy than me and he kicked off a bit to see the top man at the NHS hospital. He then got referred to a local Nuffield hospital which, at that time, was a fertility clinic. It turns out that both of us have a condition called globozoospermia. Basically a sperm should be a tadpole shape but ours are what they call "round heads". They are missing the enzyme that the sperm needs to dissolve the outer shell of the egg so it can get inside so ours literally just bounce off. There are varying degrees of this but we both have 100% so there is no way natural pregnancy will ever happen. The reason I am telling you this is that the fertility expert told me that unless you know what you are looking for a sperm sample with this condition will not look any different to a normal sample. Both me and my brother got told by our NHS hospital that our samples were "fine" when they weren't. I am not saying that this may be your problem but just trying to point out not to take the "unexplained" line as the end of it. At the time back in 2001 were were the 4th case ever recorded of brothers who both had the condition!!
Dons, I appreciate that the paragraph above may be considered giving medical advice so if you need to remove it I understand.
Anyway, we had already decided beforehand that if the last treatment we had in 2004 failed that was it and we were giving up. When the last test was negative I felt like the bottom of my world had fallen out. We nearly split up but got over it luckily. It still gets to me though. Got a couple of friends on FB who have recently had babies and the baby picture overload has just done my head in. Feel daft saying this but I feel so jealous of them that I can't have and experience that. I am a little ashamed to admit this but I have actually unsubscribed from one of them (not unfriended them) so I don't see any status updates from them as it is just too much
At the end of the day though we are both healthy and we love each other. As Lysander said earlier "some things are just not meant to be" and we did say this to each other numerous times.
Sorry if I have kind of hijacked the thread but just thought I may as well share my experience as I do know what both of them are going through right now.
BigDannyO if you want to chat about this off forums my email address is in my trust and signature.
Best of luck to you mate if you decide to carry on with the treatment