I want to use the numpad because all the keys are close by and evenly spaced.
I'm also a leftie, and for as long as I can remember I've used the HOME key group for movement, with things like reload & zoom on the numpad, under my pinkie, backspace for something essential like interact, and my thumb hovering over the big, easily distinguished SHIFT/RETURN/CTRL keys. To me it's always been a wonderfully natural way to play.
There have been times when I've had to use WASD, but then I find it much harder to easily tell the difference between keys without looking.
So you're right.
I'm still struggling to find the love for FC3 though. I am genuinely intrigued by the fact so many people can see beyond the "MASH this now!" mentality the game inflicts on us. The engine just never seems to want to get out of the way; it's always reminding me this is a game.
I wonder if part of it is to do with the fact I've never played any console games (apart from GT5). Perhaps anyone used to quicktime events, a hand-holding interface, and deliberately game-ified features like FC3's crafting and the tower unlocks will find it easier to see beyond that.
That would also explain the good reviews, because generally reviewers will have a much broader experience and be accustomed to the full range of gameplay tools developers use. Personally though this is looking like another FC2... lots of potential, but lousy design decisions which get in my way too much.
Still, there are no malaria pills, so it's not all bad. Plus I didn't pay for it directly, so I can shelve it without buyer's remorse setting in.
One thing I will say though is that if I stop thinking about this as FC3, and treat is as Just Cause 2.5 instead, it's easier to stomach. Dive in, mess things up, get bored, quit. Nice little time waster.