I wouldn’t just delete them but would run Onyx and do the maintenance tasks. I believe one of those is cleaning the dyld caches.
Odd, I'd swear that I've seen Onyx saying it's deleting that cache.
I know the thread's a couple of weeks old, but this forum is slow. I wonder if it's OS specific? Are you on Big Sur, OP? I have the option in Onyx on Catalina.
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Here's a screeny of the options on Big Sur, looks like that option has been removed: