Mine got a bug (or issue with one of my 160 installed mods) where my body disappears, but hands and feet are drawn ok, in first person view when I look down after changing my appearance. There is some fix around copying an appearance profile from a new save but that sounds long so I've started a new game since I had pretty much finished the DLC, that's also fixed it.
12GB VRAM is on the limit sometimes as is 32GB RAM, at 1440p, PT, many mods installed and get to 10.5GB VRAM and around 11GB it'll stutter and time to restart PC. Only way to make the game look any better now would be to get OLED monitor, I'm holding out for 4K and 5070 TI or some crazy 5090 system.. or not

I'm not sure 4K and 16GB VRAM would be enough! etc
Some mods are great: lower Ads volume, V dialogue replaced with female Japanese voice

, better bike feel, load to main menu, mute menu hum, hacking mini game auto complete, carrying capacity. All adds to a nicer second play through.