Programmability is now pretty insane at basically full blown programmable logic level:
https://forum.aquacomputer.de/weitere-foren/english-forum/109453-breaking-all-limits-aquasuite-x-6/
(school experience from programmable logics made configuring Aquaero easy)
If needing more than four channels I'm sure second Quadro could be added later.
At least two of them can be chained into Aquaero for extra PWM fan channels to be controlled by it.
Also Quadro "slaved" to Aquaero could be still attached directly to mobo using USB for firmware updates.
Got this answer fair month ago when asking some questions related to PC upgrade I have coming and possible changes with it:
So if possible I recommend that you keep a USB connection to the QUADRO. USB and aquabus can be connected at the same time. Please note that when aquabus is connected, it will have the higher priority for all features that can be controlled via aquabus. So for example the fan ports of the QUADRO can only be controlled through the aquaero in this case but not through QUADROs own menu. The RGBpx settings for example can be only accessed through QUADROs own menu because they do not work via aquabus.
Those tiny connectors might be "PicoBlade" type.
At least they seem to be with 1.25mm pitch.
Lightning stuff isn't usually very compatible with each others, but product page has this for Quadro:
RGBpx controller for addressable LEDs
The QUADRO controller is equipped with an RGBpx output for controlling up to 64 addressable LEDs independently. Color and brightness can be individually controlled for each LED. In total, up to four groups of LEDs of varying size can be configured, and visual effects can be assigned to each group. The 23 available effects can be extensively adjusted for further customization. Many effects can also be configured to modify effect parameters (for example speed) depending on current sensor data. The available effects also include sound-to-light effects, visualizing computer sound output. The AMBIENTpx effect deserves special notice, replicating the border area of the current monitor display on connected LEDs, allowing for an impressive background lighting surrounding the monitor.
Alternatively to the LED strips offered by Aqua Computer, LED fans made by Corsair and NZXT can be connected using the optional accessory RGBpx Splitty4 (item code 53267, not included in delivery).
So at least some fans are compatible and they have some addressable LED adapters.
Would be best to ask their support.
Pretty sure you would get thorough answer.
Support is certainly top notch considering answers I got to my questions.