Some programs just need the pagefile or they will go wrong, just leave it on.
I have 8GB and kept mine
Nice to see everyone in complete agreement on this issue
Leave it alone.
Let windows control it.
Even with 8Gig then Windows will still use virtual ram(hard drive for pagefile).
If windows was meant to NOT use it then it would not be there.
I've tried running Vista on 5GB, 6GB and 8GB without a paging file. 5GB is not reliably enough RAM. I had a couple of issues with 6GB, mostly when I was running Crysis alongside a media player, multiple internet browsers and a few smaller programs - from my experience, you'll be alright with no paging file at 6GB until you have less than about a GB free, so you just have to keep an eye on how much RAM you have free.
With 8GB I've never had a problem, and it's sufficient that I rarely bother to see how much I have free.
I've also never come across a program that has to use a paging file.. I can't see how that would work, since the paging file is essentially additional RAM for the computer that the OS allocates to ensure the computer doesn't run out (although it gets overenthusiastic and therefore uses it even when it doesn't need to, i.e. with 8GB RAM).
If you do decide to disable it (hey, you could disable it for a test and revert back if you start getting errors) it's worth first reducing the size of the pagefile to 16MB (min size) before disabling it, since Windows leaves the unused paging file on your HDD, taking up GBs of space.
And, if you decide not to disable it, you can improve performance by spreading it out over multiple drives (not partitions).