jnz instruction

When I change the JNZ instruction to JE the application runs in Ollydbg 1.10 perfectly. But when I close Ollydbg and click on the file that I changed, it pops a message which says "The file seems to be corrupt." Why is this happening? I right-clicked on the instruction that I changed. Then I...

For instance, When I change the JNZ instruction to JE the application runs in Ollydbg 1.10 with no problem. But when I close Ollydbg and click on the file that I changed, it pops a message which says "The file seems to be corrupt." Why is this happening?