Generally speaking, the answer to your question would be you'd be limited to the speed of your disk(s) rather than the network. So with a single modern consumer SATA drive I'd expect to see 150MB/s+ rear speed over 10GbE and SMB.
iSCSI would quite possibly give you a performance advantage but I doubt there'd be much in it, and as you say it comes with some inflexibility for your situation.
My setup uses 4Gb Fibre Channel to present the storage (ZFS with 6 disks, effectively RAID10) to my VMware hosts, and I have 10GbE links from each host to my main workstation (look for Mellanox ConnectX-2 EN adapters if you can, often fairly cheap). I can get around 350MB/s in a benchmark from my workstation over the 10GbE link to SMB shares on LUNs from the SAN, and copying large files isn't far off that. Even writing to a single basic disk in a host will hit the kind of speed I mentioned in the first paragraph.
The nice thing is you can then genuinely exploit the raw speed of your NAS/SAN. If you move a lot of data around regularly or do things like video editing with your material sat on your storage, it's great. And if you're anything like me then it's fun to play with too