Hi Gary,
I'm no expert so to help you i'll just quote what 8 Pack told me when i asked the very same question earlier, (hope you don't mind 8 Pack)
(8 Pack)
Good starting point for around 4.5 is 1.25 Vcore.
So into bios. Set XMP on the first setting. This sets up your RAM.
Then set turbo ratio by all cores and key in 45 to give you 4.5ghz.
Set cache Ratio to 43 for the best possible perf stability option. Lower to 42 if needed for more stability.
Move down now to Vcore and set manual and key in 1.25v,
On Cache Volts set 1.25v also.
Depending on your RAM will depend on what SA, IOD and IOA are needed. Often auto is fine but with high speed RAM and low latency adjustment may be needed.
This should be enough to start you off.
For stability testing just use the machine!!!!
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I'm now stable @4.5. 1.232 vcore, 45 on both cache ratios, tell us how you get on, will be good to compare systems as they're similar.
I think 4.6-4.7 is very possible, but i'm over the moon with the performance as is so i'm leaving it alone until it's all under water with a better Gpu.
Best of luck.