I fold on mine, nets 16k-19k ppd by itself if i leave it running. (it is overclocked quite a bit tho)
It is a little more complicated than just running the client.
You may still need to disable the SLi in nvidia control panel (this may not still be the case, as it was meant to be sorted in the recent driver releases, but i just havent tried it yet!) so both cores are accessible to CUDA.
You will need to extend you desktop across two monitors in the windows display options - if running vista or 7 then this requires you to have connected two monitor connections to the card - or a real one and a dummy plug.
you may need to use several flags to get the cards to operate correctly. I use "-gpu 1 -advmethods -forcegpu nvidia_g80" and "-gpu 0 -advmethods -forcegpu nvidia_g80". The ..g80 flag forces the drivers to accept it is possible to use the card as sometimes they decide otherwise!
When you install the client, it will go to 2 locations. In vista these are C:\Program Files (x86)\Folding@Home\Folding@home-gpu
and
C:\Users\USERNAME\AppData\Roaming\Folding@home-gpu
"AppData" is a hidden folder btw.
To run the client succesfully you need to replicate each of these folders with a 2 on the end (C:\...\Folding@home-gpu2)
You now need to create a shortcut to run each client.
In the 'Target' box put the "program files" path
In the "run in" box put the "appdata" path
If you want ot use soemthing like FahMon to monitor the clients, then the target folder it wants is the appdata one.