I normally have NOD32 on my main PC and Kaspersky on the other PC's, but when subs where up again, I trialled MSE on the other PC's, but it was instantly noticeably slowing down the laptops,
After checking various AV test places, I found F-Secure, it's cheap for 3 PC's Anti-Virus for a year if bought directly from them (£20), and this years version seemed to perform well in detection rates and resource usage, and I can testify that it's a step up from Kaspersky, and miles better then MSE for me.
I've even been running it on my main PC, I expected it to underperform against NOD32, but actually it's been really transparent, I've not noticed any performance decrease and I actually think F-Secure has a better detection rate, so I will stick with it for this year, and re-asess next year.
I've just checked the AV test sites again, and it's still performing well, almost top detection rates, and still very good on resource usage etc..