I'm assuming you have a sound card? Otherwise there would be a reason not to!
Onboard will eat some CPU power, but really nothing significant. Your only real reason might be that the drivers may conflict or some programs may throw a wobbly.
Yeah if you definitely dont need it... its one less driver, one less resource that might cuase conflicts...
On the computers in the school were I work we disable parellel ports, serial ports etc etc - the less stuff running the more stable its likely to be...
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