I was trying to run a Semp64 3000, Asus K8V-VX, 8600 GT, 80GB HDD and NEC 1300A and it failed dismally. Crashed as soon as you loaded the card, but then again you'd kinda expect that... Ran fine on the onboard stuff though, as did the Via Epia 1300 stuff in there previous to that. Noise wise it's pretty quiet, but space wise it's a bit of a pain.
I ended up shelling out for the Antec Fusion and it had more space, better cooling and a quiet/decent 430W PSU thrown in for good measure.