I'd probably make a bracket of some sort to support the weight of it, a lot of the reviews comment on how bulky and heavy the big air coolers are.
Just looking at prices and reviews - the high end air coolers in the £60-75 price range are comparable to 240mm AIO's, so the cooling ability is certainly there.
The money for two high end air coolers would only get you a pump and radiator for a custom loop, or one 240/280mm AIO, and you don't have to worry about any of the usual water cooling related issues, the main drawback is the size.
I'm thinking if you had a custom case to accomodate the size and optimise air flow to the coolers you could have a relatively quiet air cooled system as opposed to the cost of a water loop or the noise that a lot of AIO's have.
Also it's not quite related to the topic but just out of interest I did some testing with my current setup, what I don't like about normal air cooled GPU's is hot air is just blown out in all directions and is able to be recirculated back through the fans so the GPU is trying to cool itself with air that's already warm, so I made some shrouding that basically seals off the lower half of the case from the top half, and sealed around the GPU, now the GPU can only pull in fresh cool air and the exhaust air can only go out through the top of the case through the exhaust fans and it has actually dropped GPU temps by a noticable amount I was able to lower the fan speed but it's still not quiet enough.