I can't find anything on this anywhere on the web. I can't be the only one to find out. I bought the 4TB WD Black SN850X with heatsink and it seems it's incompatible with my Asus B650E-E motherboard.the problem is the Q latch system on the M.2 slots, the latch won't close as I believe the heatsink is too large. I've a 2TB version and that fits fine, smaller heatsink. There's 4 M.2 on the board and the only one removable to fit a normal spacer and screw is the one I don't want to use as it shares the GPU lanes. I've got it in there at moment. But can't believe it.