[C#] Hotkeys

[Inquisitor]

Is there any way of making use of hotkeys without making Win32 API calls? I've tried using the following:

private void MainForm_KeyDown(object sender, KeyEventArgs e)
{
    if (e.KeyCode == Keys.R && e.Modifiers == (Keys.Shift | Keys.Control))
    {
        MessageBox.Show("Hotkey pressed!");
    }
}

...but this only works when the form itself has focus, which it doesn't when there are controls on it.

Is there a simple way around this?