It is workable with adapters, but not without.
As the TX650M is a good PSU with ample power for the card, I would be tempted to try using adapters.
I suspect that you could get away with using a 6 pin to 8 pin adapter, but the way I would do it is with a dual molex to 6 pin adapter, so that you have three 6 pin connectors, and then plug the 6 pin connector from the adapter, and one of the native 6 pin connectors, into a dual 6 pin to 8 pin adapter, so that you have a 6 pin and an 8 pin connector.
Doing it like this will also ensure that you are not putting too much strain on the PSU, unlike if you were to use a dual molex to 8 pin adapter, which I would never do.