That's excellent, I always wondered how fsb speeds affected performance, and I certainly learnt something new there: exactly the reason I frequent this forum!
So, assuming my board can handle it without frying my NB, I would want a higher fsb (to compensate for lower cpu multi), lower cpu multi, and dram divider that wasn't 1:1. Or conversely if I felt my NB was a cause of instability, I would want to raise the cpu multi, lower the fsb setting, and aim for a 1:1 ram divider to relieve stress on the NB?
As for the drop in the vantage cpu score: at the same clock (4.5GHz), I experienced approximately a 7% drop over the course of about 6 months. I'd attribute that to a poorly made synthetic benchmark and varying external conditions, but the drop seemed so consistent, a hundred or two points (from 8800 total) every month or two, never any spikes. That was what confused me. I can only guess it had to do with system instability caused by degredation, but as you can tell, I only know the basics of "how" but not "why".