As you're new to all this what is the rest of you system - motherboard, processor, RAM, operating system etc? I was assuming that your sytem will run crossfire 4890's but it's best to check.
As far as cooling is concerned some basic cases might only have one intake fan and no exhaust fan or vice versa.
As long as you have decent cool airflow into the case and decent exhaust for the hot air you'll be OK.
What type of case do you have?
If you have a pre-built system from Overclockers, and it's still available, post a link.