distros.. 64 or 32 bit versions?

Either really. I can't imagine you would ever need more than 4GB memory but I think folding needs 64bit. Depends on your specific usage.
 
I've used 64-bit Arch Linux for a few years now with no issues, I also use virtualbox/wine with no problems.

Note that wine is 32bit so check the disto you are using provides the bin32 compatibility packages, Arch as full support for it.

You shouldn't notice any issues though on a mature/modern distro :)
 
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