Take a look at exclaim and codetwo exchange rules.
Exclaim requires agents (last time I looked into it) and the setup seemed pretty time consuming for it's use.
I'm currently using codetwo exchange rules on Exch2k3, it's a great little application. Requires no agents, only downside I've come across is that it gets appended server side so the end user won't get to see the signature.
You can trial a fully functional version, it'll just add an advert for itself at the bottom.
Try Mail signature manager, you can deploy via group policy or login scripts. I have been using it with our Exchange users for 2 or 3 years and it works pretty well.
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