disable windows defender real-time scanning
basically it's scans everything as you use it
better to set it to scan once daily, otherwise it'll slow down your pc
personally i do that, tweak uac (silent mode), disable hibernation, disable system restore (and offline files etc)
pro tip. 
one thing i also do (it takes a while to do manually, but i don't know of a tool to do it for you) is specify the folders you want indexed, and untick most of the filetypes that it's got selected, I only let it index.. mp3, txt, lnk, exe, avi, mkv, jpg, vob, iso, 7z, zip, rar
doing this
really speeds up your search results and doesn't have any crappy files that you don't want in it
