Flush needed when upgrading?

[1uke]

I'm upgrading a few components and adding a waterblock for my gpu. I will also be changing the fluid from a ek green variety to mayhems pastel red. Do I need to do a complete flush and take out of the rads etc? I'm guessing I do but just thought I would check.

My current system

 

[1uke]

Thanks for the reply. I did do a complete flush. And glad I did take everything out as the dust for horrible and must have been affecting the airflow badly.
It's all back in now and temps are so low with my new upgrades so I'm very pleased.