I myself have played Quake, Quake 2, UnReal Tournament 2003 and 2004 , Doom3 directly from Linux.
I have wined UT2003 and it plays pretty much the same as it does natively... I think there is a slight drop in performance but not enough to moan about, but I never compared.
Ihave recently seen info about the Dawn Of War series running under WINE but not tried it myself.
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