Have a look at the PC Design Labs QMicra V2.
The design on the top of the case makes it very easy to lug around, and it'll take full size graphics cards, and full size coolers, although a tower cooler might not be advisable if you are lugging it about). It has been designed to take a small watercooling loop, although my one has been modded to have two 120mm fans on one side, as intakes and two 120mm fans as exhausts on the opposite side.