Looks like a nice board, but again - no PCI slots. However, considering how much you are spending on the motherboard then investing in a new PCIE sound card (like the ASUS D2X) isn't a bad idea.
With the Direct Cu II coolers, these take up three slots each, if you say you want nice spacing then ideally you want at least one slot spacing between them - hence you need 8 slots (including the sound card). The MSI Big Bang Marshall can give you this (PCIE slots 1 and 5 for graphics), however, this still means that the sound card would have to be pretty close to one of the graphics cards.