Help deleting re-generating registry key ! (spybot related)

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Hi, I recently ran a spybot scan to check for nasties. To my surprise it reported on several potentially harmful entries which I swiftly deleted.

After re-running the immunize feature of Spybot (as an administrator) I get a message which reads : "The immunization could not complete, there are 15076 items still unprotected"

It goes on to say that other security software may be blocking them, but I have disabled my anti-virus and I still get the same message.

On reading the log generated by spybot it led me to the "Domains" Folder/Key in the registry. I have deleted this folder before but when I try to do so now it re-generates including all the contents which happen to be the items that Spybot cannot secure against. Included in them are some very shady looking website addresses that I have certainly not visited (yeah yeah you say but it's true !)

How can I delete the contents of this folder permanently ?

I have even tried to delete several manually to see if it made a difference to the spybot reported figure of 15076, but low and behold, they re-generate themselves again.

Can anyone please help me with this issue as I am concerned about my security

Thanks in advance.
 
I've noticed it seems to be related to Internet explorer. All the other objects immunise apart from the ones under the Internet Explorer profile. I downloaded IE9 but no difference.
 
Hi thanks a lot for the help. I couldn't settle last night knowing my computer was ill so seeing as I have the week off work I attempted to solve the problem myself before I read the replies.

After scanning with several anti malware programs and anti virus software including a boot time scan they all came up with nothing. I remembered my old friend "Hi-Jack This" and ran a scan.
On producing a logfile and having it parsed there were several entries under "015 -" relating to incorrect internet protocols and trusted website rules. Unfortunately Hi-jack this could not remove them, every time I tried they were again re-generated.

After getting increasingly annoyed I figured my machine was about due for a clean install, it's been about a year since my last one with a mobo, graphics card and ram upgrade inbetween so I bit the bullet, backed up my data and formatted the hard drive.

It's taken me most of the morning putting all my programs and settings back on, but I finally have my PC running better than ever and with no traces of the previous problem or any other.

Thanks again for the quick replies and help though.
 
Lets hope it stays that way ;)

I hope so. I've never experienced such security holes and have certainly never had so much malware turn up until I changed from Firefox to Google Chrome. I think Spybot originally picked up about 8 harmful entries including Zedo and some other pretty high rish stuff.

Needless to say I apologised to Firefox and we are friends again :D
 
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