HELP VIRUS!!! Can anyone please advice urgently

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My wife opened an email this morning and without thinking clicked on an attachment without thinking.
The computer has been completely infected all the files now end in .sh#t and are either corrupted or password protected.
The desktop has this message which is self-explanatory.

Normally in this scenario I would either do a system restore or a complete clean install.
The problem is it has not only corrupted all the files on my O/S drive, but also all the other drive with all her work.

Having scanned with windows defender I do not want to proceed further without advice. Hopefully someone here has had this same virus.







 
Given that human error was involved (opening and attachment) and Windows Defender did not protect the computer, would having any other anti-virus software installed have prevented this?


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Thanks for all the suggestions. It is a Locky extension and as everyone has said there is no ideal solution. I have disconnected my document HD and am storing it in the hope at some point in the future someone breaks the code. Until then its a clean install and back up my files on a separate system everyday.


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Ok just thinking out load.... .

If I set up a Gdrive/Dbox and sync my work folder on my desktop to it. What happens if I get infected with ransomware on my work desktop?
Won't all my files on the Gdrive/Dbox also get changed as they are are synced to the desktop folder?

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So to start this process off, wouldn't the wife have had to open the attachment and allow it to run through the Windows User Account Control popup box?

Yep, and to be fair to her she called me and told me there was an issue with the computer, but I was busy and I assumed one of her programs was playing up, so an hour later I finally went to check her screen, by that time every file was encrypted.

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