One common issue I have seen but with no concrete solution is what happens if the CCC overdrive settings are set incorrectly and subsequently cause your system to hang.
The issue is that even re-installing the drivers does not fix this, nor does removing and re-installing the card (including physical removal and re-insertion). The solution is actually rather simple, but I had to discover it myself. Boot the system into safemode using F8, open up regedit and navigate to the following key:
HKEY_CURRENT_USER\Software\ATI\ACE\Settings\Dashboard\Graphics\Overdrive5\TimeUnlocked
Change the data to NEVER
This will disable the unlocked state of the card and reset the overclocking settings back to default.
The issue is that even re-installing the drivers does not fix this, nor does removing and re-installing the card (including physical removal and re-insertion). The solution is actually rather simple, but I had to discover it myself. Boot the system into safemode using F8, open up regedit and navigate to the following key:
HKEY_CURRENT_USER\Software\ATI\ACE\Settings\Dashboard\Graphics\Overdrive5\TimeUnlocked
Change the data to NEVER
This will disable the unlocked state of the card and reset the overclocking settings back to default.