Did you need either ioh or ich or pll increase to hold stability at 4ghz? At 4.4 and having sod all fun with turbo all three of these were still at stock. pll is known to decrease stability when increased in some cases, increasing the other two without need can cause more harm than good.
If you're testing at 210x20 then life is a bit more difficult as you're starting to reach the limits of what your system is expected to do. Drop bsck until you're stable, try decreasing voltages in turn to see which can be lowered to hold stability, then increase bsck by 1 and go hunting for the numbers that have to be marginally increased. Don't just throw vcore at it.