I have the 3467-b5, best settings is really a preference thing, I had to turn my brightness way down to 7 out of 100 , contrast at default 50. Gamma on 2 default setting, some might like gamma 3 for darker blacks, in my AMD Radeon control panel I bumped up saturation for richer colours, you can do that on the monitor control panel but I find it easier with the Radeon driver software. Direct drive enabled, HDR I set to off. Eco set to off unless you find screen too bright (eco enabled you can't adjust brightness).... Black Tuner level at 0.
Colour temp set to default normal.
Blue light set to off.
Overdrive settings is really for fast paced gaming, mine is off since I play slower games but try 2 setting to start with, if you play a lot of fast paced games.
Freesync enabled for obvious reasons.
Do note if you want 165Hz refresh rate you must use a display port cable, HDMI connection I believe only does 120Hz.