Quicksaving is fine, but if you quicksave during dungeons and really hard areas. I reccomend using normal saves. I learnt that the hard way, went inside a portal had to "do something", realised I wasn't fast enough and every time I reloaded I couldn't do it and the only way to continue with the game was to cheat and fly to where I wanted.
Oh, and avoid at all costs turning into a vampire. If you like to cheat, then no problem. If you don't cheat, have fun being a vampire for ages (you only can become a vampire once in the whole game which is why it's so hard to find a cure)
Finally, do NOT kill shopkeepers, no matter how much you want the item they have in stock.
